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Be polite, open, honest, and assertive, not furtive. And never be lewd (good, old-fashioned word) or make a pass.
It's always wise to keep in mind, though, that in the workplace you should think and plan before you act. What are your positions in the company pecking order? If you do tell this colleague you're not interested in them as a partner they may claim - unfairly - that that was never their intention in the first place, craftily extricating themselves from the area of conflict, leaving a sour taste all round.
Simple is best, as it avoids too much blush inducing-babble.